Anti-Stress & Serotonin
Boost Your Mood with 5-HTP & Serotonin
Serotonin has been shown to be a key neurotransmitter linked to mood, happiness, and positive outlook. Combining the two raw building blocks of serotonin, L-tryptophan and 5-HTP, with a converting catalyst, Vitamin B6, New MOOD™ provides the nutrients to help the body become a serotonin-boosting powerhouse. Adding to the naturally relaxing effects of L-Tryptophan are a host of traditional herbs designed to support a state of peaceful calm.* Magnesium is an essential mineral vital for muscle relaxation and Vitamin D3 which is increasingly deficient in our diets, has further been linked to positive mood benefits. Ideal for when you are under occasional stress or exhaustion, New MOOD™ is also optimal for daily use.*
- Essential amino acid is the direct precursor of Serotonin.
- The best nutrient to support and enhance the body’s natural Serotonin.*
- Vitamin B-6
- One of the body’s busiest vitamins.
- Vitamin B-3
- One of the most effective natural vasodilators available.*
- Vitamin D-3
- Vital to maintaining proper blood levels of calcium and phosphorous.
Finding Your Nirvana
Stress creates cortisol which over time can wreak havoc on body chemistry. Niacin and magnesium are included in New MOOD™ along with a host of herbs with thousands of years of traditional use for helping the body to have a healthy stress response and assist in a state of calm and relaxation.* New MOOD™ is ideal before bed or any time you find yourself stressed out, down in the dumps, or a little too wired.*
Serotonin: The Natural Way
Serotonin has been linked to positive mood and healthy emotional balance. The natural production of serotonin begins with the common amino acid L-Tryptophan. L-Tryptophan converts to 5-HTP which is the direct precursor of this essential neurotransmitter (5-HT). New MOOD™ contains both L-Tryptophan and 5-HTP, creating a time release effect that when combined with Vitamin B-6, assists the body in generating strong levels of natural serotonin.*
The Science of New MOOD™
5-HTP is at the heart of this revolutionary formula, and this is no surprise as a groundbreaking published and peer-reviewed clinical study conducted by Dr. W. Poldinger confirmed the positive mood boosting effects of this nutrient.*1 Valerian, another powerful herb, was similarly demonstrated to be effective in supporting healthy asleep.*2 The formula as a whole represents the culmination of the best herbs and nutrients available, each individually helping to contribute to overall peace, tranquility, and positive mood.*
 Poldinger W, Calanchini B, Schwarz W: A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991, 24:53-81.
 Stevinson C, Ernst E: Valerian for insomnia: a systematic review of randomized clinical trials. Sleep Med 2000, 1:91-99.
New MOOD™ by Onnit™ Labs is a serotonin-boosting supplement aimed at elevating a positive affective state and promoting restful sleep. The New MOOD™ formula includes neurotransmitter precursors with the co-factor vitamin B6, catalyzing the synthesis of serotonin in the brain. Additionally, four natural extracts, with a long tradition of reducing stress and combating poor sleep, are paired with two essential vitamins and magnesium to promote a mental state of calmness and well-being.*
The Role of Serotonin
The neurotransmitter serotonin has a well-described role in regulating mood states and cognition in the human brain. A recent study correlated positive and negative mood states to the relative amount of radiolabeled C11 5-HTP, highlighting the significance of 5-HTP to serotonin conversion in the regulation of emotion (Figure 1).
Several clinical trials using the serotonin precursors 5-hydroxytrypophan (5-HTP) and tryptophan have produced strong evidence for the use of these bioactive compounds in supporting positive mood.* The inclusion of 5-HTP and tryptophan, combined with the co-factor vitamin B6 in the New MOOD™ formula, can help the body enhance the active production of serotonin within neuronal cells.
Serotonin Precursors Elevate Mood
Cells outside of the brain also produce and utilize serotonin, yet this peripheral serotonin cannot be used as neurotransmitter because of its inability to cross the blood-brain barrier. Instead L-tryptophan is ingested through diet and is enzymatically converted to 5-HTP with the help of vitamin B6. The synthesis of serotonin is regulated by the rate-limiting step of L-tryptophan to 5-HTP. In other words, supplementing the body with 5-HTP allows for a rapid conversion to serotonin production.* Meanwhile, the inclusion of L-tryptophan permits a slower, more prolonged production of serotonin.*
Several studies have tested the effectiveness of serotonin precursors in altering mood states. A Japanese study supplemented 100 patients with either 5-HTP or placebo and observed a significant support for positive mood in 69% of subjects after two weeks.* The effective delivery of serotonin precursors and their efficacy remains a topic of investigation, yet the present clinical data that exists suggests 5-HTP and L-tryptophan supplementation can aid in promoting positive mood.*
Magnesium Deficiency Linked to Low Serotonin
The lack of magnesium in most processed foods in the U.S. has made it difficult to maintain optimal levels of this important mineral. The magnesium ion plays a crucial role in gating ion channels in neuronal cells and low magnesium concentration can result in neurological dysfunction. This mechanism has led to the hypothesis that low levels of magnesium disrupt the adequate functioning of serotonergic neurons. Another study showed magnesium supplements to be useful for preventing test taking stress and elevating serotonin levels. Magnesium supplements are regarded as highly effective with few concerns for safety or toxicity.*
Natural Extracts Round Out New MOOD™
Many natural herbs have a traditional use for promoting restfulness. New MOOD™ includes chamomile, which in two recent double-blinded studies showed modest improvements in reducing mild anxiety and support for positive sleep.* Valarian root has also been systematically reviewed and tested as useful agents for promoting restful sleep in subjects who report abnormal or fluctuating sleep patterns. Lastly, lemon balm has been shown to support a positive stress response through GABA mediated inhibition and is synergistic with valerian root extract. Overall the inclusion of these natural extracts in the New MOOD™ are designed to significantly lower stress and can induce more restful sleep.*
Finding Balance with New MOOD™
The ingredients in New MOOD™ have targeted the serotonin neurotransmitter system, which is a known regulator of positive mood and sleep onset. The serotonin precursors, 5-HTP and L-tryptophan, have been shown to help the body increase the production of serotonin within the brain and serve as a natural alternative to other mood boosting solutions. The co-factor vitamin B6 strengthens the formula by catalyzing the conversion of 5-HTP to serotonin. Finally, New MOOD™ includes magnesium, an essential mineral for proper neurological functioning, and four natural extracts known to promote healthy sleep.* Each component in New MOOD™ has undergone a battery of scientific testing, and subsequent peer-reviewed studies have indicated effectiveness in respective analyses. New MOOD™ is a valuable supplement for those aiming to achieve a positive emotional state and maintain a pattern of healthy sleep.
4.)Sano I: [Treatment of endogenous depression with L-hydroxy-tryptophan (L-5-HTP)]. Nihon Rinsho 1973, 31:185-190.
Onnit Tranquility Blend
(Valerian Root Extract, Chamomile Flower Extract, Lemon Balm Leaf Extract, Jujube Seed Extract)
Valerian Root Extract:
Valerian root, scientifically known as valeriana officinalis, is a hardy, perennial flowering plant that is native to Europe and parts of Asia. Valerian root has been used since the classical era of ancient Greece as a treatment of restlessness. New clinical data supports its effectiveness in helping the body sleep restfully.*
Chamomile Flower Extract:
Another ancient and widely used herb, the chamomile flower has long been sought for its calming, anti-stress properties. Our concentrated formula is one of the strongest available on the market, and will provide effects 10x stronger than a cup of warm chamomile tea.
Lemon Balm Leaf Extract:
Lemon balm is a perennial herb in the mint family native to southern Europe and the Mediterranean regions. Studies have shown lemon balm to be helpful to the body in maintaining positive mood.*
Jujube Seed Extract:
The Jujube tree has its origins in China but has rapidly been cultivated throughout the world due to the prized properties of both the fruit and the seed. The seed in particular is widely used as an herbal treatment for restlessness. Three specific compounds found within the seeds have been researched in regards of this effect: flavonoids, saponins, and polysaccharides.*
L-Tryptophan is an essential amino acid found naturally occurring in turkey and other proteins. It is the building block for 5-HTP, the direct precursor of Serotonin, however it is also available to convert to Melatonin, aiding in restfulness and sleep.*
The direct precursor and metabolic intermediate of serotonin, 5-HTP is the best nutrient to restore and enhance the body' natural supply of Serotonin.*
Pyridoxine (Vitamin B-6) is one of the body's busiest vitamins, involved in an estimated 101 chemical reactions. One of its primary tasks is to aid in the manufacturing of amino acids and neurotransmitters, including serotonin.*
Ever feel happier after being in the sun? Vitamin D-3 is vital to maintaining proper blood levels of calcium and phosphorous, among many other important functions. Recent evidence suggests that it is difficult for the body to maintain optimum levels of Vitamin D through sunlight and nutrition alone.*
Vitamin B-3 (Niacin)
Vitamin B3 is one of the most effective natural vasodilators available. Opening up capillaries and blood vessels, Niacin allows the restorative power of oxygenated blood to cleanse and detoxify the system. *
Magnesium is needed for hundreds of your body's basic functions, including regulating your heart, blood pressure and nervous system. Promoting a sense of muscular and physical calm, magnesium is commonly used to combat occasional stress and restlessness.*
Ratings & Reviews
What's in Onnit New MOOD
Directions For New MOOD: Suggested Use: Adults, as a dietary supplement, take two capsules in the evening prior to sleep. A serving of two capsules may be taken during the day for occasional stress support. Do not exceed six capsules in any 24-hour period.
Warnings: Consult a medical doctor before taking this or any other nutritional supplement if you are pregnant, nursing, have or suspect a medical condition or are taking any medications. Store at room temperature, in a cool, dry place. KEEP OUT OF REACH OF CHILDREN.